Alzheimer's Research and Non-human Primates
Non-human primates are invaluable towards the research of Alzheimer's disease since aged monkeys naturally develop deposition of amyloid-beta peptide: a trademark characteristic of Alzheimer's disease. Researchers are able to use these primate models with plaque depositions in the brain to model Alzheimer's disease for study of the disease itself and treatment. Although, there are problems with natural models since it usually takes years for the plaques to naturally develop in a way that models Alzheimer's disease, but now researchers are able to induce amyloid plaques in the brains of middle-aged monkeys by injecting amyloid-beta42 and thiorphan making the models develop much faster than natural causes. Researchers can use these primates models to study development of Alzheimer's disease, effects of Alzheimer's disease, and test treatments for Alzheimer's disease.
Li, Wende, Wu, Yu'e, Min,Fangui, Li, Zhuo, Huang, Jianyun, et al. (2010). A nonhuman primate model of Alzheimer's disease generated by intracranial injection of amyloid-beta42 and thiorphan. Retrieved from http://search.proquest.com.proxy189.nclive.org/docview/807459660?pq-origsite=summon
Li, Wende, Wu, Yu'e, Min,Fangui, Li, Zhuo, Huang, Jianyun, et al. (2010). A nonhuman primate model of Alzheimer's disease generated by intracranial injection of amyloid-beta42 and thiorphan. Retrieved from http://search.proquest.com.proxy189.nclive.org/docview/807459660?pq-origsite=summon